Search results for "Staphylococcal enterotoxin B"

showing 1 items of 1 documents

Modulation of Contact Sensitivity Responses by Bacterial Superantigen

1995

Superantigens are potent modulators of the immune system, especially T cells. Therefore, we determined the influence of superantigens on the T-cell-mediated immune response, contact sensitivity. We chose the combination of staphylococcal enterotoxin B (SEB) as superantigen and 2,4-dinitrofluorbenzene (DNFB) as the contact sensitizer, because in BALB/c mice SEB reacts almost exclusively with V beta 8+ T cells, and these cells are capable of transferring contact sensitivity to DNFB from sensitized donors to naive syngeneic recipients. Pretreatment with a single intradermal injection of 50 ng SEB 24 h before DNFB exposure at the same site on the lower abdomen enhanced the induction of contact …

Lymphoid Tissue24-dinitrofluorbenzeneReceptors Antigen T-Cell alpha-betaT-LymphocytesDown-Regulationchemical and pharmacologic phenomenaDermatologyEnterotoxinDermatitis Contactcontact sensitivityBacterial superantigenBiochemistrysuperantigenProinflammatory cytokineEnterotoxinsInterferon-gammaMiceImmune systemmedicineSuperantigenAnimalsIntradermal injectionMolecular BiologySensitizationSkinAntigens BacterialMice Inbred BALB CSuperantigensbusiness.industryhemic and immune systemsCell BiologyContact sensitivitybiological factorsStaphylococcal enterotoxin Bmedicine.anatomical_structureImmunologyDinitrofluorobenzeneFemaleImmunizationbusinessJournal of Investigative Dermatology
researchProduct